منابع مشابه
Aberrant LncRNA Expression Profile in a Contusion Spinal Cord Injury Mouse Model
Long noncoding RNAs (LncRNAs) play a crucial role in cell growth, development, and various diseases related to the central nervous system. However, LncRNA differential expression profiles in spinal cord injury are yet to be reported. In this study, we profiled the expression pattern of LncRNAs using a microarray method in a contusion spinal cord injury (SCI) mouse model. Compared with a spinal ...
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The Wnt signaling pathway is essential in the development and homeostasis of blood and immune cells, but its exact role is still controversial and is the subject of intense research. The malignant counterpart of normal hematopoietic cells, leukemic (stem) cells, have hijacked the Wnt pathway for their self-renewal and proliferation. Here we review the multiple ways dysregulated Wnt signaling ca...
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WT1 is a transcription factor expressed in hematopoietic stem cells and in most cases of myeloid leukemia. We investigated the roles of hypoxia and epigenetics in the regulation of WT1 expression in myeloid leukemia cells. WT1 expression correlates with hypomethylation of the CpG island in Intron 1, and pharmacologic demethylation of this CpG island induces WT1 mRNA expression. Hypoxia causes d...
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UNLABELLED Long noncoding RNAs (lncRNA) have been found to play a role in gene regulation with dysregulated expression in various cancers. The precise role that lncRNA expression plays in the pathogenesis of B-acute lymphoblastic leukemia (B-ALL) is unknown. Therefore, unbiased microarray profiling was performed on human B-ALL specimens, and it was determined that lncRNA expression correlates w...
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t cell acute lymphoblastic leukemia (all) is an invasive disease with a higher incidence in children and adolescents. in terms of immunophenotype, t-all is positive for cd2, cd7, cd34 and hla-dr, and the level of these markers is increased with increasing age. in addition, the myeloid markers (cd13, cd33) are sometimes expressed in t-all. in this study, we introduce a rare case of a 28-year-old...
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ژورنال
عنوان ژورنال: Journal of Cancer
سال: 2020
ISSN: 1837-9664
DOI: 10.7150/jca.42093